Month: June 2026

Introduction and Objective: Food Is Medicine interventions are being promoted to improve glycemic control in type 2 diabetes mellitus (T2D), but limited randomized trial (RCT) data exist. We evaluated the efficacy of a scalable, technology-based grocery prescription program in low-income, high-risk adults with T2D.Methods: We conducted a 1:1 RCT in Kaiser Permanente Northern & Southern […]

Introduction and Objective: Food insecurity leads to worse type 2 diabetes (T2D) outcomes, but which food insecurity intervention best improves T2D outcomes is unclear. Our objective was to compare the effectiveness of two food insecurity interventions: medically tailored meals (MTM) and food subsidies.Methods: Randomized comparative effectiveness trial (NCT04828785). Adults with T2D and food insecurity received […]

Introduction and Objective: Diabetes damages retinal mitochondria and impairs their removal by mitophagy, and these damaged mitochondria continue to accumulate. Diabetes also results in aberrant expression of many long noncoding RNAs (LncRNAs), the RNA transcripts with >200 nucleotides. These noncoding RNAs can interact with RNA, DNA and proteins, regulating many physiological processes. Among them, LncRNA […]

Introduction and Objective: Irisin is a hormone secreted by skeletal muscle following physical activity or exposure to excess saturated fatty acids, promoting energy expenditure and insulin secretion. Circulating irisin levels are reduced in patients with type 2 diabetes (T2D), while exogenous irisin administration improves glycemic control in diabetic mice. Interestingly, irisin and GLP-1 share pleiotropic […]

Introduction and Objective: We compared perinatal outcomes among pregnancies complicated by type 2 diabetes (T2D) managed with continuous glucose monitoring (CGM) to self-monitored blood glucose (SMBG).Methods: Patients with pre-pregnancy T2D, singleton gestation, and delivery between 2018-2024 at two health systems were identified by ICD-10 codes. Patient demographics and outcomes were abstracted and compared between those […]

Introduction and Objective: Many people living with T1D do not achieve glycemic targets, and the risk of severe hypoglycemia persists. HDV-L restores postprandial hepatic glycogen storage by presenting insulin to hepatocyte receptors as a dense molecular aggregate, improving receptor signaling. The OPTI-2 study evaluated the impact of HDV-L on A1C and hypoglycemia risk.Methods: In a […]

Introduction and Objective: Recurrent iatrogenic hypoglycemia blunts the counterregulatory response (CRR) to hypoglycemia. This study tested the hypothesis that RH induces insulin resistance and that the insulin sensitizer, pioglitazone, prevents the development of insulin resistance and consequently prevents the development of a blunted epinephrine response to hypoglycemia.Methods: 8-10-week-old rats were randomized to 1 of 3 […]

Introduction and Objective: A recent randomized crossover trial compared a next-generation algorithm for Omnipod (Omnipod 6) with the first-generation Omnipod® 5 Automated Insulin Delivery System in a diverse population of adults (T1D/T2D) and children (T1D). Assessing performance of Omnipod 6 in those with T2D is needed given the unique pathophysiology, insulin needs, and concomitant therapy […]

Introduction and Objective: To evaluate the efficacy and safety of mazdutide (MAZ) 9 mg, a once-weekly GLP-1 and glucagon receptor dual agonist, in Chinese adults with obesity.Methods: In this randomized, double-blind, placebo (PBO)-controlled trial (NCT06164873, GLORY-2), 462 Chinese adults with obesity (BMI ≥30 kg/m2; 16.0% with T2D) were randomized in a 2:1 ratio to receive […]

Introduction and Objective: The conventional hypoglycemic clamp utilizes high-dose IV insulin at fixed rates to induce target hypoglycemia, lacks standardized protocols and results in insulin overdose affecting spontaneous recovery. This improved hypoglycemic clamp procedure adjusts for individual insulin sensitivity and assesses “time to spontaneous recovery” as a critical endpoint.Methods: 12 healthy (41±12 yrs, 28±2 kg/m2) […]