Month: June 2026

Introduction and Objective: The high cost of insulin hinders access and utilization of insulin, a life-sustaining medication, for U.S. adults with diabetes. By 2025, 27 states and DC have passed and implemented insulin out-of-pocket (OOP) caps, but the reach of these caps is uncertain. In this study, we estimate the population being protected by state […]

Introduction and Objective: Emerging adults (EAs) with type 1 diabetes (T1D) face elevated A1c levels and diabetes distress. Continuous glucose monitors (CGM) improve outcomes, but little is known about CGM breaks – particularly during this developmental period. Using mixed methods, we investigated the prevalence, drivers, behaviors during, and impacts of CGM breaks through surveys and […]

Introduction and Objective: CGM and GLP-1 receptor agonists (RA) are two distinct and increasingly used treatment strategies in T2D, each associated with meaningful improvements in clinical outcomes. However, there is little real-world evidence comparing their effectiveness in primary care or evaluating whether combined use offers added benefit in HbA1c and body weight (BW).Methods: We conducted […]

Introduction and Objective: Obesity is a serious health issue for Indigenous Americans residing in Arizona and genetic factors are believed to play a role in the development of this chronic disease. The aim of this study was to identify and mechanistically study variants that associate with BMI. We identified 3 variants associated with BMI located […]

Introduction and Objective: Survodutide, a dual glucagon/GLP-1 receptor agonist in phase 3 trials for obesity and metabolic dysfunction-associated steatohepatitis, contains a C18-diacid half-life extension (HLE) group for once weekly dosing. This study thoroughly investigated the in vitro receptor pharmacology of survodutide and the impact of its HLE using time-resolved cellular assays.Methods: GCGR and GLP-1R both […]

Introduction and Objective: GDM dietary therapy targets maternal glycemia in gestation but fails to address postpartum metabolic disease risk. In an RCT, pregnant women on a higher-complex CHO diet showed an improved OGTT response at 36 wks’. We studied the diets’ sustained effect 2 mos postpartum (PP).Methods: At diagnosis, women with diet-managed GDM were randomized […]

Introduction and Objective: The hallmark of T1D is the destruction of pancreatic insulin producing β-cells by autoreactive T cells. The quest for new antigen-specific autoreactive cells as well as for strategies that may target them are highly required to provide a more successful therapeutic option for T1D. Starting from many evidence suggesting a potential role […]

Introduction and Objective: Metformin is an increasingly common medication used in pregnancy. However, metformin crosses the placenta raising concerns about unintended long-term effects to offspring health. This study examined whether metformin exposure during early development alters skeletal muscle metabolism in juvenile offspring and increases the risk of insulin resistance and obesity.Methods: Adult female Rhesus macaques […]

Introduction and Objective: Harmine (H) plus Exendin-4 (E) robustly enhances human β cell regeneration, yet whether H+E influences human β cell senescence is unknown. We developed a computational framework to resolve senescence heterogeneity in scRNA-seq and applied it to test whether H+E modulates senescence programs in cytokine-challenged vs. unchallenged human islets.Methods: We developed a machine-learning […]