Introduction and Objective: Efsubaglutide alfa (Suba) is a novel GLP-1RA. ENLIGHT is a seamless Phase 2b/3 program; the Phase 2b stage evaluated Suba regimens to inform dose selection for the subsequent Phase 3 study.Methods: This double-blind, placebo (PBO)-controlled trial (NCT06921486) randomized participants to Suba 5, 10, or 20 mg once weekly (QW), 20 mg once […]
Read MoreMonth: June 2026
Why Are Ultra-Processed Foods So Bad for You? Study Offers Insight
Share on PinterestThe manufacturing processes used to produce ultra-processed foods are linked to negative impacts on human health. Image Credit: Andy Sacks/Getty Images A recent study has found that it may not just be what’s in ultra-processed foods that makes them unhealthy, but how they’re made. The study noted that factors such as changes in […]
Read More2674-P: Adaptations of Juvenile Offspring Islets to Maternal Overnutrition and Metformin in a Nonhuman Primate Model
Introduction and Objective: Use of the oral glycemic agent metformin (Met) in pregnancy has expanded beyond treatment of maternal diabetes, but effects on offspring metabolic health are understudied. Met is not metabolized by the maternal liver and is transported across the placenta, and in humans is associated with small for gestational age, increased postnatal catch-up […]
Read More1992-P: Impact of Primary Care Availability on Adverse Effects of Social Vulnerability on Diabetes Outcomes
Introduction and Objective: Access to primary care and social determinants of health (SDOH) both impact diabetes care. We aimed to determine whether primary care (assessed as primary care physician [PCP] supply) modifies the association between SDOH and measures of diabetes care among Medicare beneficiaries.Methods: We used 2022 county data on PCP supply from the Area […]
Read More1748-P: IGlarLixi Improves PPG and DTIR in Asian People with T2D (PwT2D): Post Hoc Pooled Analysis of Ph3 Studies
Introduction and Objective: Ph3 studies have compared iGlarLixi vs individual components (LixiLan-O-AP, LixiLan-L-CN) or IDegAsp (SoliD) in Asian PwT2D. This pooled analysis investigated the effect of iGlarLixi on PPG and SMPG derived time in range (dTIR).Methods: Changes in SMPG profile were analyzed in the pooled iGlarLixi vs control arms of LixiLan-O-AP, LixiLan-L-CN and SoliD.Results: Baseline […]
Read More1143-OR: A Causal Framework for Evaluating Baseline Determinants of One-Year Graft Function after Islet Transplantation
Introduction and Objective: Despite substantial metabolic benefit, islet transplantation (ITx) shows variable graft durability, with ~30% of recipients not sustaining function over time. We used mixed effects regression within a causal directed acyclic graph (DAG) framework to describe baseline determinants of 1 year graft function.Methods: We evaluated data from 415 ITx recipients from the Collaborative […]
Read More1553-P: Youth and Provider Input in Adapting a Single-Session Depression Intervention for Type 1 Diabetes
Introduction and Objective: Up to 30% of youth with type 1 diabetes (T1D) report elevated depressive symptoms, which negatively impact T1D management. Behavioral health interventions exist to improve mood and promote treatment engagement, but their high cost and long duration are implementation barriers. Further, <25% of youth with T1D referred for mental health services attend […]
Read More2922-LB: Improving Diabetes Technology Access for Patients with Disabilities
Introduction and Objective: Patients with diabetes and intellectual, developmental, and physical disabilities (IDPD) often have worse glycemic control and greater complications but may be overlooked when prescribing diabetes technology. This project aimed to increase insulin technology prescriptions at an academic center by 15% in patients with diabetes and IDPD over one year using a physician […]
Read More1452-P: Adipose Tissue Insulin Resistance: Associated Factors and Sex Differences across Obesity and Dyslipidemia Status
Introduction and Objective: Adipose tissue insulin resistance(IR) is related with metabolic disorders. However, evidence regarding sex differences in adipose IR remains limited. This study aimed to identify factors associated with adipose IR and to examine sex differences and their potential modifiers.Methods: This cross-sectional study included 9,935 adults undergoing routine physical examinations. Adipose IR index(Adipo-IR) was […]
Read More1160-OR: Empowerment through Visibility: Lived Experiences with CGM vs. Routine Care in Adults with Type 2 Diabetes Not on Insulin
Introduction and Objective: Adults with T2D not treated with insulin face distinct and ongoing self-management challenges. This qualitative study explored how CGM versus routine care (RC, without CGM) impacts psychological, behavioral, and emotional outcomes in this population.Methods: Semi-structured interviews were conducted virtually with a randomly selected subset of participants from the CONNECT randomized trial at […]
Read More