Share on PinterestRecent studies have shown that the age of menopause onset can influence various health outcomes. The Good Brigade/Getty Images One study found that early natural menopause may be associated with a 27% higher risk of metabolic syndrome. Another study shows that later-onset menopause may have a lower risk of heart attack and stroke. […]
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Share on PinterestDoes the hit TV series “The Pitt” accurately depict what it’s like to work in a real ER? Photograph by Warrick Page/HBO Max This month, “The Pitt” won a Golden Globe, including Best Drama Series and Best Actor for Noah Wyle. The Emmy-winning emergency medicine drama is driving conversation across entertainment and healthcare. […]
Read MoreAbatacept, a cytotoxic T lymphocyte–associated protein 4 immunoglobulin that inhibits T-cell costimulation, was evaluated for 12 months in stage 1 type 1 diabetes (T1D) to delay disease progression. Despite modest preservation of area under the curve C-peptide at 12 months, the primary end point was not met. We adopted the oral minimal model (OMM) to […]
Read MoreType 1 diabetes (T1D) is an autoimmune disease characterized by β-cell destruction promoted by autoreactive T cells. Eukaryotic translation initiation factor 4E (eIF4E)–binding protein 1 (4E-BP1) and 4E-BP2 are translational repressors and downstream targets of mammalian target of rapamycin complex 1 (mTORC1). Activation of the 4E-BP2/eIF4E pathway by 4E-BP2 deletion promotes translation initiation, inducing β-cell […]
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Share on PinterestThe 75 Medium challenge may help people build healthy, sustainable habits that lead to weight loss and improved fitness. Getty Images 75 Medium is a new trend that’s gaining popularity on social media platforms like TikTok. It’s designed as a more sustainable alternative to the 75 Hard challenge. It includes daily movement, flexible […]
Read MoreEarly postprandial glucagon concentrations are higher in type 1 diabetes (T1D) than in individuals with no diabetes (ND). To determine the cause, we infused stable [13C9, 15N1]glucagon before, during, and after a mixed meal in 16 ND and 16 T1D individuals to measure glucagon turnover. In a subcohort of 9 ND and 12 T1D individuals, […]
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Share on PinterestMany children’s medical offices and state health departments aren’t in compliance with the CDC’s new child vaccine guidelines. Robert Michael/picture alliance via Getty Images Pediatric medical professionals are pushing back against new CDC recommendations that implemented major changes to the childhood immunization schedule. Many pediatricians rely on advice from the American Academy of […]
Read MorePreclinical studies suggest that activating branched-chain amino acid (BCAA) catabolism may improve chronic kidney disease (CKD). In this prospective clinical study, we sought to examine the association between urinary BCAA excretion and risk of CKD progression in patients with type 2 diabetes. Baseline urinary BCAAs were measured by mass spectrometry in 1,868 outpatients with type […]
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Share on PinterestThe United States recorded a 33-year high in measles cases in 2025, the highest level of U.S. measles cases since 1992.Jan Sonnenmair/Getty Images The United States is at risk of losing its measles elimination status, which it has held since 2000. The designation may be revoked because in 2025, the U.S. experienced its […]
Read MoreB lymphocytes are thought to drive β-cell destruction in type 1 diabetes (T1D) by activating anti-islet T cells. However, the observation that autoreactive T-cell activation and disease progression can occur without B cells challenges this view. Still, preclinical and clinical studies have shown that B-cell depletion alleviates β-cell destruction, suggesting a critical role for B […]
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