Month: December 2025

Preclinical studies show that dietary or central administration of monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs) can reduce food intake, enhance energy expenditure, and attenuate hypothalamic inflammation (HI), whereas saturated fatty acids (SFAs) promote weight gain, HI, and neuronal injury. However, whether hypothalamic exposure to different fatty acids similarly influences HI and body […]

There is significant evidence that acute stress, a challenge to an organism’s homeostasis, has dramatic effects on metabolic control. Acute stress impairs blood glucose control in people with both type 1 and type 2 diabetes. In addition, growing evidence suggests that metabolic responses to stress in people without diabetes may be a crucial determinant of health. […]

Gestational diabetes mellitus (GDM) is defined as hyperglycemia first identified during pregnancy and can lead to adverse maternal and neonatal outcomes. The molecular mechanisms leading to these outcomes are currently poorly understood. While transcriptomics of GDM placentas has been previously studied, the effect on precursor mRNA splicing remains largely unknown. This study explores the impact […]

Publisher’s Note. Simon A. Hawley, Rebecca J. Ford, Brennan K. Smith, Graeme J. Gowans, Sarah J. Mancini, Ryan D. Pitt, Emily A. Day, Ian P. Salt, Gregory R. Steinberg, and D. Grahame Hardie. The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels. Diabetes 2016;65:2784–2794. https://doi.org/10.2337/db16-0058 Source link

Each month, the Diabetes editorial team chooses a single paper to be designated the Paper of the Month, which is then made available for free online and added to an exclusive collection (https://diabetesjournals.org/collection/1619/Diabetes-Paper-of-the-Month). Congratulations to the 2025 winners! Source link

Issues and Events Source link

Establishing the relevance of a genetic variant in the causality of a given disease is crucial. Clinical molecular geneticists use a variety of tools including mode of inheritance, segregation in the family, penetrance, and determination of the variant as loss of function (LOF) or gain of function (GOF). However, this approach to determining how a […]

It has never been a bigger problem than now: it is estimated that more than 800 million people have chronic kidney disease (CKD) and diabetes is the leading cause of CKD, all projections say that prevalence of both type 2 diabetes and CKD will increase in the coming years, and CKD is expected to become […]

A key question for scientists as they raced to understand SARS-CoV-2: what was the human entry point for the virus that causes COVID-19? The answer, angiotensin-converting enzyme 2 (ACE2), was a protein Susan Gurley had studied for decades, not as a virologist but as a nephrologist. “I still study ACE2 in the context of kidney […]