Share on PinterestReclassification of cannabis will offer certain coverage for Medicare recipients. Image credit: Virginian Pilot/Getty Images A White House directive is ordering federal authorities to speed up the reclassification of a form of cannabis as a less dangerous drug. The action may also establish a pilot program that allows Medicare recipients to be reimbursed […]
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Share on PinterestResearch shows that certain foods can affect your mood in different ways, including making you happier. Image Credit: Ani Dimi/Stocksy Research shows that certain foods can affect your mood in different ways. A recent study notes that a diet that is high in ultra-processed foods and refined carbohydrates can increase a person’s risk […]
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Share on PinterestYoung adults with a higher risk of metabolic syndrome may benefit from eating nuts, researchers say. fcafotodigital/Getty Images A new study suggests that swapping high carb snacks for nuts can help curb sweet cravings. Participants at risk for metabolic syndrome who made the switch also tended to increase their protein intake. Nuts are […]
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From multivitamins to crafting with friends, the ‘Strangers With Candy’ star shares her recipe for staying mentally sharp and young at heart. Share on PinterestActor and comedian Amy Sedaris shares her approach to healthy aging and cognitive well-being. Image credit: Axelle/Bauer-Griffin/Getty Images The macabre humor of Amy Sedaris may not be for the faint of […]
Read MorePancreatic β-cell ATP-sensitive K+ (KATP) channel closure underlies electrical excitability and insulin release, but loss or inhibition of KATP channels can lead to paradoxical crossover from hyperinsulinism plus hypoglycemia, to glucose intolerance or diabetes. We report genotype-phenotype information from a set of patients clinically diagnosed with maturity-onset diabetes of the young (MODY) and carrying coding […]
Read MoreAccurate prediction of diabetic kidney disease progression is challenging, but mandatory. Urinary Dickkopf-3 (uDKK3), a tubular, epithelial-derived glycoprotein and marker of tubular injury, is a promising biomarker for kidney function decline. We explored the clinical utility of uDKK3 to predict kidney function decline and adverse cardiovascular events in patients with type 2 diabetes mellitus (T2DM) […]
Read MoreType 1 diabetes (T1D) is characterized by autoimmune destruction of insulin-producing β-cells. Recent evidence has implicated hybrid insulin peptides (HIPs) as targets of autoreactive CD4 T cells in human T1D patients and as critical autoantigens recognized by diabetogenic T cells in nonobese diabetic (NOD) mice. HIPs form within pancreatic islets through cross-linking reactions between proinsulin […]
Read MoreMaternal obesity is a known risk factor for metabolic dysfunction in offspring; however, its effect on metabolism during pregnancy in female offspring remains unclear. This study investigated how maternal obesity, induced by high-fat (HF) feeding in C57BL/6J mice, affects the metabolic adaptation to pregnancy in female offspring. Dams were fed an HF diet (60% fat) […]
Read MoreHyperglycemia (HG) is a well-established risk factor for secondary osteoporosis, primarily due to suppressed osteoblast activity. While gut microbiota (GM) dysbiosis has been implicated in various diseases, its role in HG-induced osteoporosis remains poorly understood. Here, we demonstrate that HG mice develop low-turnover osteoporosis accompanied by reduced GM diversity. Fecal microbiota transplantation (FMT) from HG […]
Read MoreVascular dysfunction is considered a consequence of diabetes. However, in pancreatic islets, some hemodynamic changes occur before the onset of symptoms. The underlying mechanisms driving islet vascular abnormalities have not been fully characterized, but islet pericyte dysfunction seems to be an early event in the pathogenesis of type 1 diabetes in humans. It remains to […]
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