Introduction and Objective: Diabetic nephropathy is one of the most important complications of diabetes mellitus. In recent years, exercise has been reported to be potentially effective in preventing nephropathy. However, the relationship with resistance training(RT) is not clear. In this study, we researched the effect of resistance RT on the progression of nephropathy in patients with type 2 diabetesMethods: We analyzed retrospectively the cohort study of type 2 diabetic patients (T2DM) with urinary albumin-to-creatinine ratio (UACR) under 30 mg/gCr who visited Ayabe City Hospital from April 2020 to March 2022 and were observed until May 2024. The progression of nephropathy was defined as UACR of 30 mg/gCr or higher during observation period. Participants were asked how many times per week they engaged in RT and the average duration per session. Individuals who performed RT at least once per week were classified as RT participants. Hazard ratio of RT for the progression of nephropathy was calculated by Cox hazard model after adjusting by age, gender, BMI, hemoglobin A1c(HbA1c), smoking states, alcohol consumption, physical activity, sitting time, sarcopenia, use of RAS inhibitor and use of SGTL2 inhibitors at baseline.Results: 266 patients (173 men), mean age, body mass index, HbA1c, UACR, RT and median observation period were 72.0 ± 13.2 years, 23.7 ± 3.5 kg/m2, 7.2 ± 0.7 %, 56.8 ± 137.4 mg/gCr, 44 participant(16.5%) and 981 (260-1269) days. Participants who engaged in RT performed it an average of 4.6 times per week, with a mean duration of 13.8 minutes per session. During follow-up, progression of nephropathy was observed in 39.1 % (104/266). The adjusted hazard ratio of RT of progression of nephropathy was 0.55 (95% confidence interval 0.30-0.98, P = 0.033).Conclusion: Patients with T2DM with RT were shown to be at lower risk of developing diabetic nephropathy. This suggests that RT is important in terms of preventing diabetic nephropathy.
T. Osaka: None. M. Fukui: None.
Source link
Leave a Reply