Introduction and Objective: Gestational diabetes (GDM) increases risk of type 2 diabetes (T2D). We examined associations between nativity and glucose tolerance at 6-9 wks postpartum in women with recent GDM.Methods: 995 women with GDM and without T2D based on 2-h 75g oral glucose tolerance tests were classified with normoglycemia (fasting <100 and 2-h post-load <140 mg/dL) or prediabetes (fasting 100-125 and/or 2-h post-load 140-199 mg/dL) at 6-9 wks postpartum. Poisson regression models estimated adjusted prevalence ratios (aPR) and 95% confidence intervals (CIs) of prediabetes associated with US-born status adjusted for covariates.Results: Mean cohort age was 33.4 y with 36.8% Asian, 7.7% Black, 30.4% Hispanic, 1.5% Native/Multi-race, and 23.6% White. Overall, 49.5% were non-US born (79.2% Asian and 52.7% Hispanic). At 6-9 wks postpartum, 34.1% of women were classified with prediabetes (44.5% Asian and 28.3% Hispanic). Compared to US-born, being non-US born was associated with higher risk of prediabetes [aPR = 1.39 (1.16-1.67)] adjusted for clinical and social factors (age, NDI, health insurance type) and established risk factors (family history of T2D and BMI) (Table 1).Conclusion: Non-US born women with GDM were 39% more likely to have prediabetes at 6-9 wks postpartum even after accounting for social risk factors. Further research should explore underlying social determinants to develop targeted interventions for T2D for non-US born mothers.
W.F. Munoz Orozco: None. B.B. Thapa: None. A.S. King: None. M. Duggan: None. E.P. Gunderson: None.
The National Institute of Diabetes, Digestive and Kidney Diseases (R01 DK118409); National Institute of Child Health and Human Development (R01 HD050625)
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