Category: Diabetes

Introduction and Objective: Presymptomatic Stage 2 type 1 diabetes (T1D) is characterized by ≥2 autoantibodies and dysglycemia due to a progressive decline of β-cell function, eventually leading to symptomatic Stage 3 T1D. We aim to develop a risk progression model with the potential to assess the effectiveness of therapeutic interventions to delay T1D onset.Methods: Twenty-three […]

Introduction and Objective: Type 2 Diabetes (T2D) can lead to ischemic conditions in lower limbs and the following risk of diabetic foot ulcer (DFU). Data linking vitamin D and lower extremity arterial plague (LEAP) and its adverse event, i.e. DFU, are limited.Methods: We enrolled 7479 hospitalized patients (2378 men and 3105 women aged 30 to […]

Introduction and Objective: The use of sodium-glucose co-transporter 2 inhibitors (SGLT2i) in diabetes treatment is expanding. This study evaluated the efficacy and safety of henagliflozin combined with continuous subcutaneous insulin infusion (CSII) in type 2 diabetes (T2DM) based on continuous glucose monitoring system (CGM).Methods: In this multicenter, randomized, open-Label, controlled study, 210 patients who had […]

Introduction and Objective:IntroductionAdvancements in blood glucose measurement and insulin dosing over the past two decades have improved outcomes for individuals with Type 1 diabetes (T1D). However, chronic kidney disease (CKD) remains a significant management challenge. The frequency of specialist outpatient (OP) appointments could serve as a proxy for disease severity. This study aimed to determine […]

Introduction and Objective: Guidelines recommend GLP-1 receptor agonists (GLP-1-RA) and SGLT2 inhibitors (SGLT2i) for individuals with type 2 diabetes (T2D) at high risk of atherosclerotic cardiovascular disease (ASCVD). We aimed to develop a personalized treatment algorithm to guide the initial decision between these therapies.Methods: Using data from the Diabetes Prospective Follow-up registry (Germany/Austria) we studied […]

Introduction and Objective: Continuous glucose monitoring (CGM) is a diagnostic tool widely used to monitor glucose levels in patients with diabetes and to guide insulin dose adjustments in outpatients. In the critical setting of inpatient care, however, special regulatory requirements on glucose measurements necessitate accuracy of CGM measurements as a prerequisite for its integration into […]

Introduction and Objective: Diabetes mellitus is a common complication after solid organ transplant (SOT). Sodium-glucose cotransporter inhibitors (SGLT2i) have shown significant cardio-renal benefits in people with type 2 diabetes. However, their use in SOT recipients remains underexplored in the existing literature. We aimed to perform a systematic review and meta-analysis to evaluate the efficacy and […]

Introduction and Objective: This study examines the impact of online, virtual patient simulation (VPS)-based continuing medical education (CME) on performance related to diagnosis and management of T2D by diabetologists/endocrinologists (D/Es) and primary care physicians (PCPs).Methods: Intervention was 2 patient scenarios presenting in a VPS. Clinical guidance (CG) based on evidence was provided following each decision, […]

Introduction and Objective: Ketones are energy substrates, serving as a “superfuel” for the heart, skeletal muscle, etc.. Our previous work showed that 3-hour intravenous (IV) exogenous ketones (KE) improved left ventricular function in T2D patients with HFrEF by up to 6%, dose-dependently. However, IV delivery is invasive and impractical for daily use. This study explores […]

Introduction and Objective: Type 2 diabetes (T2D) is marked by impaired insulin secretion and action in metabolic organs like adipose tissue and skeletal muscle. Aberrant gene expression contributes to T2D. Alternative polyadenylation (APA) alters gene expression by producing mRNA isoforms with variable 3’ UTR lengths. The 3’ UTR interacts with trans-factors, affecting mRNA stability, translation, […]