We read with interest the article by Uddin et al. (1) that was recently published in Diabetes. The authors present an in vivo imaging methodology using HYPOX-4 to visualize retinal hypoxia in early diabetes. This approach may help advance our understanding of diabetic retinopathy (DR) pathophysiology and aid in identifying preclinical biomarkers. Source link
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Issues and Events
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Read MoreComment on Lin et al. Reconsidering Adipose Tissue Lipolysis Dysfunction: Evidence for a Distal Machinery Defect Beyond Insulin Resistance
In their recent article in Diabetes, Lin et al. (1) report an exceptionally strong correlation (r = −0.93) between insulin- and niacin-mediated suppression of FFA-palmitate Ra. Because these agents act through distinct proximal signaling pathways, this correlation, not only notable, is mechanistically constraining and directly informs the interpretation of adipose tissue (AT) dysfunction in obesity and […]
Read MoreCD8 + Memory T Cells Encode Obesogenic Memory in White Adipose Tissue
Obesity is associated with systemic energy imbalance and leads to a wide range of metabolic complications, including type 2 diabetes, fatty liver disease, and cardiovascular disorders. Therapeutic strategies for obesity, including lifestyle interventions such as exercise and dietary modification, bariatric surgery, and glucagon-like peptide 1 receptor agonists, have been widely implemented (1). However, rapid weight […]
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GLP-1 Drugs Like Ozempic, Mounjaro Can Quiet ‘Food Noise’
Share on PinterestGLP-1 drugs may help reduce food cravings, leading to healthier eating habits that contribute to weight loss. Image Credit: Juan Moyano/Stocksy A recent study found that using GLP-1 drugs, such as Ozempic and Mounjaro, can help reduce food cravings. The researchers found that GLP-1 medications can reduce “food noise” better than behavioral therapy […]
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Wegovy Helps Reduce Migraine Severity, Especially in Women
Share on PinterestA new study found that women using semaglutide had a reduction in their use of triptans, a drug commonly prescribed for migraine. Victor Bordera/Stocksy A study has found that treatment with semaglutide led to reduced triptan usage in women. However, no significant effect was observed in men with overweight or obesity. Experts say […]
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Special Edition: What's Next—Cortisol, Metabolism & Future Innovation, Part 4
Is hypercortisolism the hidden culprit in a significant proportion of both difficult-to-treat diabetes and resistant hypertension? In part 4 of our special series, Dr. Neil Skolnik speaks with John Buse, MD to explore the effects of hypercortisolism, until just recently considered a vanishingly rare condition. This special episode is sponsored with support from Corcept. Please […]
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GLP-1s Like Ozempic, Wegovy May Lower Blood Pressure
Share on PinterestResearch shows that GLP-1s may help lower blood pressure levels. Image Credit: Tatiana Maksimova/Getty Images A recent study found that GLP-1 drugs like Ozempic and Wegovy may significantly reduce blood pressure. The positive results were observed alongside weight loss and independently of it. The findings add to growing evidence to support the meaningful […]
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Real Housewives Star Says She Likes Herself Better After Breast Cancer
Real Housewives of Miami star Guerdy Abraira says her breast cancer journey has given her a “different type of strength and confidence.” Share on PinterestReal Housewives of Miami star Guerdy Abraira. Photos courtesy of Guerdy Abraira\ “My breast was very dense to the point where [my doctor said], ‘We’re not touching anything until you get […]
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6.4 to 7.8 Hours a Night May Slow Biological Aging
Share on PinterestRecent research has found an association between sleep duration and biological aging. Image Credit: ArtistGNDphotography/Getty Images A recent study found that too little or too much sleep may speed aging in the brain and other organs. The study used aging clocks to examine associations between sleep and various mental health and medical conditions. […]
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