Author: sugaradmin

Introduction and Objective: We examined the association between a composite social determinant of health (SDOH) score and incident coronary heart disease (CHD), adjusting for genetic susceptibility to CHD and traditional risk factors, among adults with T2D.Methods: We used data from 71,916 All of Us Research Program (AoU) participants with T2D who are free of CHD. […]

Introduction and Objective: While diabetic ketoacidosis (DKA) prediction models have been successfully developed using electronic health record (EHR) data, incorporating continuous glucose monitoring (CGM) metrics may further improve risk stratification. To explore this possibility, we examined the association between CGM metrics and DKA events in adults with type 1 diabetes (T1D).Methods: We identified adults with […]

Introduction and Objective: The protein kinase A (PKA) signaling cascade is the core signaling pathway of hepatic gluconeogenesis. However, the mechanisms governing PKA nuclear translocation remain incompletely understood. In this study, we identified the nuclear membrane protein TMEM201 (transmembrane protein 201) as a critical regulator of PKA nuclear translocation.Methods: PKA catalytic subunits were used as […]

Introduction and Objective: A high intake of dietary fiber has been shown to improve glycemic management in individuals living with Type 2 diabetes (T2D). We developed FiberMore, a generative AI-based mobile app grounded in the Theory of Planned Behavior, to address inadequate fiber intake in individuals with T2D, and assessed its efficacy in increasing fiber […]

Introduction and Objective: Human pluripotent stem cell-derived pancreatic β-like cells (hPSC-β cells) represent a promising cell source for diabetes therapy. However, their clinical translation is hampered by time- and cost-intensive differentiation protocols. Establishing a scalable expansion system for hPSC-derived pancreatic endoderm (progenitor) cells (hPSC-PEs) would enable accessible regenerative therapies.Methods: To identify the mechanisms limiting their […]

Introduction and Objective: Short-term use of a single stand-alone 14-day continuous glucose monitoring (CGM) improves glycemic awareness and self-management in non-insulin-treated (NIT) patients with type 2 diabetes (PwT2D). This study examined whether supplementing short-term CGM use of 9-14 days with access to a digital learning platform or a blended in-person course and webinar enhances self-reported […]

Introduction and Objective: Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by chronic immune activation and stromal remodeling; however, the paracrine mechanisms linking parenchymal metabolic stress to immune-stromal responses remain poorly understood. This study aimed to identify key paracrine signals driving inflammatory and fibrogenic remodeling in MASH and to define their downstream mechanisms.Methods: Integrative transcriptomic and secretome […]

Introduction and Objective: Older adults benefit from continuous glucose monitoring (CGM) use, but CGM initiation and sustained use often require intensive educator support, and time requirements are poorly characterized. We quantified educator time and support needs during the REST study.Methods: REST is a prospective 12-month study conducted in older adults (≥65 years) with insulin-treated diabetes, […]