Introduction and Objective: Although small studies note that PCOS affects up to 1 out of 4 women with T1D, whether this applies to T1D more broadly is unknown. It is also unknown if PCOS confers cardiovascular disease (CVD) risk among youth with T1D, who are already at elevated risk. We examined whether PCOS was associated with higher AS in SEARCH, a U.S. population-based study of youth onset diabetes.Methods: Participants underwent assessments of pulse-wave velocity (PWV) at ~17 and again at ~22 years of age. Females were asked if they had been diagnosed with PCOS by a physician. This analysis included females with T1D and ≥1 assessment of AS (n=853). AS was defined as PWV ≥ 6.8 m/s. Using generalized estimating equations which accounted for repeated PWV measures, we examined whether PCOS was associated with higher AS.Results: Among women with T1D, PCOS (n=45, 5.2%) was associated with less favorable CVD risk factors and higher AS (Table). After adjustment for age, race/ethnicity, site, diabetes duration, waist circumference, mean arterial pressure, and smoking, PCOS was associated with AS (odds ratio 2.08, 95% confidence interval 1.09, 3.99).Conclusion: Among females with T1D, who are at high risk for CVD, PCOS is associated with further increases in CVD risk after consideration of traditional risk factors.
C. Kim: None. A. Bellatorre: None. K. Reynolds: Research Support; Merck & Co., Inc. L.M. Dolan: None. C. Pihoker: None. Z. Yin: None. H. Huddleston: Other Relationship; Allara Health. Research Support; Rejoni, May Health. J.K. Snell-Bergeon: Stock/Shareholder; GlaxoSmithKline plc. D. Dabelea: None.
The SEARCH for Diabetes in Youth Cohort Study (1R01DK127208?01, 1UC4DK108173) is funded by the National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, and supported by the Centers for Disease Control and Prevention. The Population Based Registry of Diabetes in Youth Study (1U18DP006131, U18DP006133, U18DP006134, U18DP006136, U18DP006138, and U18DP006139) is funded by the Centers for Disease Control and Prevention (DP-15-002) and supported by the National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention and the National Institute of Diabetes and Digestive and Kidney Diseases.
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