Introduction and Objective: Type 1 Diabetes Mellitus (T1DM) poses a substantial global health burden, particularly among adolescents and young adults. This study examines trends in Disability-Adjusted Life Years and mortality associated with T1DM from 1990 to 2021.Methods: Data on DALYs and mortality for individuals aged 15-39 years were collected from Global Burden of Disease study and analyzed using Joinpoint regression models. APC and AAPC were calculated to identify temporal trends. Statistical significance was determined using p-values (<0.05).Results: From 1990 to 2021, T1DM caused a combined 495562 deaths and 40819490 DALYs. DALYs exhibited a slight overall decline (AAPC: -0.0657, 95% CI: -0.098 to -0.028, p = 0.0016), with the most significant reduction from 2000 to 2012 (APC: -0.8420, 95% CI: -0.946 to -0.750, p = 0.0192). However, a slight increase was noted between 2012 and 2021 (APC: 0.2190, 95% CI: 0.091 to 0.375, p = 0.0128). Mortality rates declined more pronouncedly (AAPC: -0.3514, 95% CI: -0.387 to -0.3088, p < 0.000001), with the decrease during 2000-2011 (APC: -1.4747, 95% CI: -1.841 to -1.400, p < 0.000001). Slight increases occurred during 2014-2017 (APC: 0.8121, 95% CI: 0.340 to 1.134, p = 0.0044).Conclusion: While the global burden of T1DM has generally declined, periods of increasing trends highlight the need for sustained public health efforts and research into contributing factors.
M. Haider: None. H. Ahmad: None. I.A. Magsi: None. M. Kakakhel: None. U. Hayat: None. I. Ahmad: None.
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