Introduction and Objective: The utility of lactate as an indicator of metabolic dysfunction during pregnancy is unknown. This study determined if blood lactate is related to established markers of metabolic dysfunction (insulin resistance, obesity, substrate oxidation) in pregnancy. Methods: Respiratory quotient (RQ) and blood was collected before and serially after a high-fat meal. Glucose and insulin values were used to calculate HOMA and MATSUDA index. Lactate was also assessed. To assess meal response, area under the curve (AUC) values were calculated for glucose, insulin, lactate and RQ. Participants were stratified into pre-pregnancy BMI groups (lean, overweight, obese). Kruskal-Wallis tests were used to compare groups. Spearman’s rank-order correlation coefficients were used to assess associations between variables. Partial correlations adjusted for pre-pregnancy BMI.Results: Participants (N=61) in late pregnancy (34.5+/-1.7weeks) were recruited. There were significant differences in lactate between groups (p<0.05, Table). Lactate AUC was significantly correlated to insulin AUC, RQ AUC, HOMA-IR, and MATSUDA (p<0.004). These associations remained significant even after controlling for pre-pregnancy BMI (p<0.004).Conclusion: Lactate is related to established markers of metabolic dysfunction, including insulin resistance, substrate oxidation and obesity, in late pregnancy.
D.D. Pearson: None. C.G. Tucker: None. N.T. Broskey: None. R. Purvis: None. N. Zite: Research Support; Merck & Co., Inc. K.B. Fortner: Other Relationship; Pfizer Inc. C. Reeder: None. J. van Nes: None. M.M. Blankenship: None. R.A. Tinius: Stock/Shareholder; Bumptup Labs INC. J.M. Maples: None.
University of Tennessee Graduate School of Medicine Women in Science & Coffman Pediatric Funding
Source link
Leave a Reply