Introduction and Objective: Glycemic variability, a key determinant of diabetes-related complications, remains a challenge in diabetes management. Time with rapid glucose change (TRC) has recently been proposed as a metric for assessing glycemic variability. There are no published data addressing the potential for AID to reduce TRC. BCDiabetes has a high volume of clients using OS AID with the apps Loop, iAPS and AAPS, and fully permissioned access to their data for research purposes.Methods: This retrospective analysis included all OS AID clients with paired Time in Range (TIR) at baseline and at 60 days. TIR was measured over 14 days using glucose target 3.9-10.0 mmol/L. TRC was defined as % time with glucose changing at >0.55 mmol/L per 5 minutes. Analysis used paired t-tests, with subgroups of baseline TIR of <50% and >70%.Results: 522 clients were studied of whom 33% were pediatric, 47% male, average age 32 years and average duration of T1 15 years. See Table 1 below.Conclusion: This is the first evidence supporting a role for AID in reducing TRC, particularly in individuals with TIR < 50% and invites validation. With validation TRC might be included in standard CGM reporting. In the future high TRC may be used as a further indication for the use of AID as standard care in T1D.
A. Alqahtani: None. N. Khan: None. K. Hawke: None. T. Elliott: None.
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