Introduction and Objective: Negative comments on body image and visible weight loss from friends, family, and peers may influence treatment discontinuation. This study evaluated societal influences reported treatment discontinuation with GLP along with weight regain.Methods: This observational study included adults on GLP-1-based therapy for weight loss with a minimum follow-up of 1 year. Weight loss was categorized and weight regain was assessed among individuals who discontinued therapy for reasons other than adverse effects. Participants with weight regain were asked to report reasons for discontinuation, and societal comments were thematically summarized.Results: Total of 167 adults were included; 47.3% were younger than 45 yrs, 60.8% were female, and 72.2% had a baseline BMI≥30 kg/m². After at least 1 year of therapy, 82.2% achieved ≥5% weight loss, 62.0% achieved ≥7-10%, 43.0% achieved ≥10-15%, and 15.2% achieved ≥15-20% weight loss; non-response was observed in 17.7%. Seventeen participants (26.15%) experienced weight regain after discontinuing therapy for non-adverse-effect reasons, frequently citing negative societal comments after weight loss: perceptions of appearing ill, weak, or prematurely aged. (Table1).Conclusion: Negative societal comments may influence discontinuation of GLP-1-based therapy, highlighting the role of nutrition, exercise, and social attitudes in long-term weight-loss sustainability.
J. Kesavadev: None. A. Basanth: None. A. Ashik: None. K. Jothydev: None. G. Sanal: None. S. Joshi: None. A. Shankar: None.
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