Introduction and Objective: CGMs help millions of people manage their diabetes. These use passive sensors that have performance and usability limitations. IMS uses semiconductor and nano technologies to create a highly miniaturized electrochemical sensor, the CGM+. It uses a multi-sensor array and sends multiplexed data to an external transmitter, which processes and relays it to a smartphone via BLE. It also has a tissue temperature sensor. This is the first CGM to provide multi-sensor, multi-modal, and multi-analyte data.Methods: In this study, the CGM+ sensor is tested along with leading commercial CGMs. Fingerprick readings using a Contour SMBG meter (reference) are compared against readings from the CGMs over multiple days.Results: The study shows that the IMS CGM+ tracks the reference glucose values and works accurately during daily routine activities like sleeping, running, eating, and showering. Figure 1 shows that CGM+ can accurately track reference readings from Contour SMBG.Conclusion: These results demonstrate the human feasibility of monitoring glucose over multiple days using an integrated sensor array based on a single semiconductor device. Such a system can become a next-generation diabetes monitoring platform that can accurately monitor metabolic (e.g., glucose in v1, glucose and ketones in v2, glucose, lactate, ketones in v3) and physiological (e.g., temperature) parameters using a single device. It provides robust data for closed-loop glucose control.
M. Mujeeb-U-Rahman: None. J.H. Heithaus: Consultant; Jiangsu Jumao X-Care. A. Nadir: None. M. Honarvar Nazari: None.
National Institutes of Health (1SB1DK142387-01)
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