992-P: A Retrospective Comparative Study of Glycemic Control Metrics at Six Months in 133 Patients with Type 1 Diabetes after Switching from isCGM to rtCGM with the Same Sensor Profile

by sugaradmin



Introduction and Objective: In Japan, FreeStyle Libre 2 (Libre 2)​ was approved as real-time continuous glucose monitoring (rtCGM) only when used smartphone application since its initial release, December 2023. Because early approval as rtCGM like Japan is uncommon, the efficacy of switching from intermittently scanned CGM (isCGM) to rtCGM with identical accuracy and specifications remains unclear.Methods: This retrospective study included adults with type 1 diabetes. Changes in HbA1c and CGM metrics were assessed ​before and 6 months after ​switching from isCGM to rtCGM. ​In patients switched from isCGM to isCGM with ​low and high glucose alert function​s (​Libre 2 reader users), due to ​difference of ​release day between the ​reader and app, only 3-month data were analyzed.Results: Of 133 patients enrolled from January 2024 through June 2024. 67 (50.4%) were male​; the mean (±SD) age of the patients was 45.6 ± 15.3 years and HbA1c ​was 7.51 ± 0.64%. At 6 months post-​switching, significant improvements were observed in mean HbA1c (7.51 vs. 7.35, p < 0.01), TAR (37.5% vs. 35.3%, p < 0.01), TIR (58.7% vs. 61.4%, p < 0.01), TITR (37.6% vs. 39.0%, p = 0.04), CV​ (38.0​% vs. 36.3​%, p < 0.01) and MAGE (127.3​mg/dL vs. 118.9​mg/dL, p < 0.01). No significant differences were ​o​bserved for TBR (3.72% vs. 3.33%, p = 0.13) or Level 2 TBR (0.51% vs. 0.38%, p = 0.16). Similar effects on HbA1c and CGM metrics were observed in a 3-month analysis.​ On the other hand, 35 patients ​switched from isCGM to isCGM with alert function​s showed no significant differences in HbA1c, TIR, TAR, and TBR at 3 months.Conclusion: Switching from isCGM to rtCGM improved glycemic control at 6 months in patients with type 1 diabetes. The lack of improvement in HbA1c and CG​M metrics in patients using isCGM with alert function​s suggests monitor​ing ​real-time glucose levels​, rather than alert​ functions, may play a crucial role in achieving better ​glucose outcomes.

Disclosure

D. Sekiguchi: None. Y. Maeda: None. M. Morita: None. Y. Kurogi: None. M. Minami: None.



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