For many years, brown adipose tissue (BAT) was primarily regarded as a “heat organ” for rodents. Over the past 15 years, however, research in this field has shifted significantly toward understanding of the role of BAT in metabolic health, including systemic glucose homeostasis, lipid metabolism, insulin sensitivity, and protection against cardiometabolic disease. In this award […]
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Genetic Variants Increasing TAS2R38 Bitter Taste Receptor Sensitivity Are Associated With Lower Postprandial Glycemia
TAS2R38 is a bitter taste receptor that influences bitter taste perception and diet and is also found in intestinal L cells that store and secrete glucagon-like peptide 1 (GLP-1). Preclinical studies have linked TAS2R38 activation to postprandial GLP-1 secretion, fueling interest in TAS2R38 as a therapeutic target for glucose regulation; however, evidence in humans remains […]
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Issues and Events Source link
Read MoreThe Dark Proteome: “Not Everything That Counts Can Be Counted”
Juvenile Diabetes Research Foundation International10.13039/1000009012-SRA-2024-1550-S-B. Source link
Read MoreBeyond the Classical Axis: Metabolic “Pressure” on the Adrenal Gland?
Ministry of Research MURNext Generation EU PNRR PRIN project P2022EA9RR, Source link
Read MoreFrom Methylation to Metabolism: Linking Molecular Layers in Diabetes Risk
Type 2 diabetes risk has traditionally been assessed using fasting glucose, BMI, and lipid panels (1). Although these measures are easily accessible and scalable, they capture disease only after metabolic dysfunction has already been established, limiting the potential for prevention and hindering the effectiveness of interventions (2). This gap has motivated efforts to develop molecular […]
Read MoreDiabetes Spotlight: Sylvaine You, PhD—Preventing the Progression of Type 1 Diabetes Through Immunomodulatory Therapeutics
Science means constantly learning. “You have to constantly question yourself, because our understanding of the world changes all the time. We may have thought something 20 years ago which isn’t true anymore,” Sylvaine You says. “But it’s also very exciting, because you’re constantly discovering. New proteins, new molecules, new pathways, new mechanisms—it’s such a dynamic […]
Read MoreNUAK1 Promotes Diabetic Kidney Disease by Accelerating Renal Tubular Senescence via the ROS/P53 Axis
Diabetic kidney disease (DKD) progression involves intricate interactions among senescence, oxidative stress, inflammation, and fibrosis. This study systematically investigates the regulatory role and molecular mechanisms of NUAK1 in DKD pathogenesis. Bioinformatics analysis of Gene Expression Omnibus data sets identified NUAK1 as a differentially expressed gene, validated in human kidney proximal tubule epithelial (HK-2) cells, high-fat […]
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Does Aluminum in Vaccines Cause Peanut Allergies? What Experts Think
Share on PinterestExperts say there is no credible scientific evidence that aluminum in vaccines causes peanut or other food allergies. heather diehl/Getty Images HHS Secretary Robert Kennedy Jr. says aluminum in vaccines may be a factor in a child developing a peanut allergy. Experts say Kennedy’s comments are not based on credible scientific evidence. Children […]
Read MoreSpecial Edition – CVOTs Part 2
In this special series on The Cardiovascular Outcome Trials our host, Dr. Neil Skolnik will discuss the history and importance of the Cardiovascular Outcome Trials for diabetes medications. In Part 1 we discussed an historical perspective with Dr. Steven Nissen. Today we discuss with Dr. Darren McGuire the incredible evolution of the CVOTs since that […]
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