Obesity may increase end-stage kidney disease risk in women with type 2 diabetes


diabetes
Credit: CC0 Public Domain

Obesity may negatively affect kidney function in people with type 2 diabetes, particularly in women, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.

Diabetic nephropathy, or the deterioration of kidney function in people with diabetes, is caused by and high blood sugar. Approximately one in three adults with diabetes has , and kidney diseases are the ninth leading cause of death in the United States. Kidney disease progresses over time to end-stage renal disease, and people with end-stage often need a kidney transplant to stay alive.

“Our research highlights how obesity contributes to the incidence and progression of in people with type 2 diabetes, especially for women,” said Zhi-Hong Liu, M.D., of Jinling Hospital and Nanjing University School of Medicine in Nanjing, China “Managing your blood pressure and blood sugar may not be enough to slow the progression to end stage renal disease, and our study shows how important it is for people with diabetes to also manage their weight.”

The researchers analyzed data from 158,284 East Asian adults from the BioBank Japan Project. Genetic evidence showed that higher body mass index levels were associated with an increased risk of diabetic kidney disease and decreased kidney filtration rate levels in 3,972 people with type 2 diabetes. Body mass index was not causally associated with increased levels of protein in the urine. Women with obesity and type 2 diabetes had a greater risk of diabetic kidney disease than men.

“People with diabetes and obesity should have their kidneys checked more often as they are at high risk, and while chronic kidney disease has no cure, early detection and obesity treatment could slow the progression to end-stage kidney disease,” Liu said.


Obesity is more prevalent in people with type 1 diabetes than previously thought


More information:
Jingru Lu et al, Body Mass Index and Risk of Diabetic Nephropathy: A Mendelian Randomization Study, The Journal of Clinical Endocrinology & Metabolism (2022). DOI: 10.1210/clinem/dgac057

Citation:
Obesity may increase end-stage kidney disease risk in women with type 2 diabetes (2022, February 22)
retrieved 22 February 2022
from https://medicalxpress.com/news/2022-02-obesity-end-stage-kidney-disease-women.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.





Source link

You may also like...

Leave a Reply

Your email address will not be published. Required fields are marked *